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Raltegravir central nervous system tolerability in clinical practice: results from a multicenter observational study

Madeddu, Giordano and Menzaghi, Barbara and Ricci, Elena and Carenzi, Laura and Martinelli, Canio and Di Biagio, Antonio and Parruti, Giustino and Orofino, Giancarlo and Mura, Maria Stella Anna and Bonfanti, Paolo (2013) Raltegravir central nervous system tolerability in clinical practice: results from a multicenter observational study. AIDS, Vol. 26 (18), p. 2412-2415. eISSN 1473-5571. Article.

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DOI: 10.1097/QAD.0b013e32835aa141

Abstract

Central nervous system (CNS) symptoms have been reported in clinical trials and case reports in patients receiving raltegravir. We investigated CNS symptoms in 453 HIV-infected patients. Of these 47 (10.4%) developed at least one drug-related CNS symptom. Predictors of CNS symptoms were concomitant therapy with tenofovir or with proton pump inhibitors that can increase raltegravir concentration. Thus, our data suggest a possible correlation between high raltegravir plasma concentrations and CNS symptoms, and therefore their monitoring in clinical practice.

Item Type:Article
ID Code:8917
Status:Published
Refereed:Yes
Uncontrolled Keywords:Central nervous system (CNS) symptoms, raltegravir plasma concentrations
Subjects:Area 06 - Scienze mediche > MED/17 Malattie infettive
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:Lippincott Williams & Wilkins
eISSN:1473-5571
Copyright Holders: © 2012 Lippincott Williams & Wilkins, Inc.
Deposited On:24 Apr 2013 14:58

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