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Analysis of epidermal growth factor receptor (EGFR) status in endometrial stromal sarcoma

Capobianco, Giampiero and Pili, Francesca and Contini, Marcella and De Miglio, Maria Rosaria and Marras, Vincenzo and Santeufemia, Davide Adriano and Cherchi, Claudio and Dessole, Margherita and Cherchi, Pier Luigi and Cossu Rocca, Paolo Alessandro (2012) Analysis of epidermal growth factor receptor (EGFR) status in endometrial stromal sarcoma. European Journal of Gynaecological Oncology, Vol. 33 (6), p. 629-632. ISSN 0392-2936. Article.

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Abstract

Purpose: Endometrial stromal sarcomas (ESSs) are rare neoplasms, which are currently treated by surgery, whereas effective adjuvant therapies have not yet been established. Recently, epidermal growth factor receptor (EGFR) expression has been described in ESS, and a potential role of EGFR-targeted adjuvant therapies has been proposed. The aim of this study was to analyze EGFR status in an ESS series and to evaluate their potential role as molecular targets. Materials and Methods: EGFR status was investigated in a total of ten cases of ESS, which included seven low-grade ESS and three undifferentiated ESS cases. EGFR expression levels were assessed by immunohistochemistry, and gene amplification analysis was performed with dual-color fluorescence in situ hybridization (FISH). Results: Nine out of ten ESS cases showed positive immunostaining, whereas FISH analysis demonstrated constantly negative results. Conclusions: This study confirmed that EGFR is frequently overexpressed in ESS. FISH analysis did not show EGFR amplification in any of the tumors, therefore EGFR expression in ESS should be related to different genetic mechanisms.

Item Type:Article
ID Code:8914
Status:Published
Refereed:Yes
Uncontrolled Keywords:EGFR, Endometrial Stromal Sarcoma (ESS), immunohistochemistry, FISH
Subjects:Area 06 - Scienze mediche > MED/40 Ginecologia e ostetricia
Area 06 - Scienze mediche > MED/08 Anatomia patologica
Area 06 - Scienze mediche > MED/04 Patologia generale
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Clinica e Sperimentale
Publisher:IROG Canada
ISSN:0392-2936
Deposited On:24 Apr 2013 09:39

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