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Serum thiols and cardiovascular risk scores: a combined assessment of transsulfuration pathway components and substrate/product ratios

Mangoni, Arduino A. and Zinellu, Angelo and Carru, Ciriaco and Attia, John R. and McEvoy, Mark (2013) Serum thiols and cardiovascular risk scores: a combined assessment of transsulfuration pathway components and substrate/product ratios. Journal of Translational Medicine, Vol. 11 (1), p. 9. eISSN 1479-5876. Article.

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DOI: 10.1186/1479-5876-11-99

Abstract

Background: Serum thiols have shown associations with surrogate markers of cardiovascular disease. However, little information is available on their combined association with validated cardiovascular risk scores for primary prevention at population level. We sought to determine whether individual serum thiol concentrations and substrate/product ratios within the transsulfuration pathway are independently associated with such scores.
Methods: Data on clinical and demographic characteristics, serum thiols (homocysteine, cysteine, taurine, glutamylcysteine, total glutathione and cysteinylglycine) and high-sensitivity C-reactive protein (CRP) were collected from a sample of the Hunter Community Study without previous cardiovascular events [n=350, median age (IQR) = 62 (59--66) years]. Five-year absolute cardiovascular risk score for each subject was calculated using the Framingham Risk Equation.
Results: Median risk score was 7% (IQR 4--10). After adjusting for body mass index, estimated glomerular filtration rate and physical activity regression analysis showed independent associations between cardiovascular risk scores and a) higher serum homocysteine (B 0.066, 95%CI 0.040 to 0.091, P<0.001) and lower cysteine (B -0.003, 95%CI -0.005 to -0.001, P=0.003) and glutathione (B -0.029, 95%CI -0.056 to -0.003, P=0.03) concentrations; and b) higher homocysteine/cysteine (B 0.114, 95%CI 0.066 to 0.161, P<0.001) and lower glutathione/cysteinylglycine (B -1.145, 95%CI -2.030 to -0.260, P=0.011) ratios. No significant associations were observed between cardiovascular risk scores, taurine and CRP.
Conclusions: Serum homocysteine, cysteine and glutathione are independently associated with cardiovascular risk scores at population level. Enzymatic pathways involved in reduced bioconversion of homocysteine into cysteine and increased glutathione degradation might play an important role in such associations.

Item Type:Article
ID Code:8905
Status:Published
Refereed:Yes
Uncontrolled Keywords:Thiols, transsulfuration, cardiovascular risk, epidemiology, risk assessment
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:BioMed Central
eISSN:1479-5876
Copyright Holders:© 2013 Mangoni et al.
Publisher Policy:Depositato in conformità con la politica di copyright dell'Editore
Deposited On:19 Jun 2013 08:46

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