Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella and Kowalik-Jankowska, Teresa and Kozlowski, Henryk (2005) Nickel binding to Cap43 protein. In: 8. FIGIPAS meeting in inorganic chemistry, 6-9 July 2005, Athens, Greece. Conference or Workshop Item.
Cap43 has been reported to be specifically induced by nickel compounds in a variety of cell lines. Although the function of Cap43 protein (MW 43,000) is not clear, it does appear to be induced in response to an increase in intracellular concentration of Ca2+, caused by nickel ion exposure in cultured human cells, for this reason is named Cap43: Calcium protein 43,000. Cap43 protein is expressed at low levels in normal tissues however, it is overexpressed in cancer cells. The high level of expression in cancerous status combined with the elevated stability of Cap43 protein makes it an excellent cancer marker.
I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore
Repository Staff Only: item control page