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Nickel binding to Cap43 protein

Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella and Kowalik-Jankowska, Teresa and Kozlowski, Henryk (2005) Nickel binding to Cap43 protein. In: 8. FIGIPAS meeting in inorganic chemistry, 6-9 July 2005, Athens, Greece. Conference or Workshop Item.

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Abstract

Cap43 has been reported to be specifically induced by nickel compounds in a variety of cell lines. Although the function of Cap43 protein (MW 43,000) is not clear, it does appear to be induced in response to an increase in intracellular concentration of Ca2+, caused by nickel ion exposure in cultured human cells, for this reason is named Cap43: Calcium protein 43,000. Cap43 protein is expressed at low levels in normal tissues however, it is overexpressed in cancer cells. The high level of expression in cancerous status combined with the elevated stability of Cap43 protein makes it an excellent cancer marker.
A possible way to better understand the molecular mechanisms implicated in toxicity and carcinogenicity of nickel compounds is to study the characteristics of the proteins expressed by the genes specifically induced by these carcinogens. For this reason we focused our attention to investigate the interaction ability of nickel to Cap43 protein. The peculiarity of Cap43 protein is in its new mono-histidinic motif consisting of ten amino acids TRSRSHTSEG fragment repeated three times in the C-terminus.

Item Type:Conference or Workshop Item (Presentazione)
ID Code:8878
Status:Published
Uncontrolled Keywords:Nickel binding, Cap43 protein
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Additional Information:Abstract pubblicato in: 8. FIGIPAS Meeting in inorganic chemistry: 6-9 July 2005 Athens, Greece. - Atene : [s.n.], 2005. - PP13.
Deposited On:09 May 2013 12:50

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