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NMR study of Nickel binding to N-tail of histone H4

Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella (2005) NMR study of Nickel binding to N-tail of histone H4. In: 8. FIGIPAS meeting in inorganic chemistry, 6-9 July 2005, Athens, Greece. Atene, [s.n.]. PP14. Conference or Workshop Item.

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Nickel has been shown to be an essential trace element involved in the metabolism of several species of bacteria, archea, plant and may yet be found to play a role in the metabolism of higher organisms. However, the carcinogenicity of certain nickel compounds has been confirmed by the combination of epidemiological evidence in humans and carcinogenesis bioassays in animals. The molecular mechanisms of nickel-induced carcinogenesis include interactions of this metal with major chromatin components causing alterations in gene expression rather than by direct and mammalian cells. It has preference to specific lysine residues in the N-terminal tail of histone H4, in which the sites of acetylation are clustered.
Here we present our recent results on the coordination ability of Ni(II) to the N-terminal tail of Histone H4 using NMR spectroscopy. A series of 1D, 2D Tocsy and Noesy 1H NMR spectra of the tail with increasing nickel concentration to the final molar ratio 1:1, were acquired.

Item Type:Conference or Workshop Item (Paper)
ID Code:8877
Uncontrolled Keywords:NMR studies, nickel binding, histone H4
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Deposited On:09 May 2013 11:48

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