Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella (2005) NMR study of Nickel binding to N-tail of histone H4. In: 8. FIGIPAS meeting in inorganic chemistry, 6-9 July 2005, Athens, Greece. Atene, [s.n.]. PP14. Conference or Workshop Item.
Nickel has been shown to be an essential trace element involved in the metabolism of several species of bacteria, archea, plant and may yet be found to play a role in the metabolism of higher organisms. However, the carcinogenicity of certain nickel compounds has been confirmed by the combination of epidemiological evidence in humans and carcinogenesis bioassays in animals. The molecular mechanisms of nickel-induced carcinogenesis include interactions of this metal with major chromatin components causing alterations in gene expression rather than by direct and mammalian cells. It has preference to specific lysine residues in the N-terminal tail of histone H4, in which the sites of acetylation are clustered.
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