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Interaction of Cu(II) ions with a fragment of Park9 protein

Medici, Serenella and Peana, Massimiliano Francesco and Solinas, Costantino and Zoroddu, Maria Antonietta (2012) Interaction of Cu(II) ions with a fragment of Park9 protein. In: Copper in biology: 8. International copper meeting, September 30-October 5, 2012, Alghero, Italy. [S.l.], [s.n.]. p. 66, P29. Conference or Workshop Item.

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Abstract

Parkinson Disease (PD) is a neurodegenerative pathology whose causes have not yet been fully clarified.
In this perspective, we have chosen short fragments of Ypk9 protein that include interesting sequences for metal binding and are highly conserved in a number of different organisms, located in domains of the protein readily accessible to the metals. We studied their behaviour towards divalent cations such as manganese and zinc, using NMR mono- and bidimensional techniques and EPR spectroscopy. As this study was going on, we also started the investigation on Cu(II) coordination, showing by a series of potentiometric and spectroscopic measurements that this metal too is able to effectively bind the chosen sequence. Here we would like to report our latest findings.

Item Type:Conference or Workshop Item (Poster)
ID Code:8846
Status:Published
Uncontrolled Keywords:Copper(II), Parkinson's disease
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Area 03 - Scienze chimiche > CHIM/01 Chimica analitica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:[s.n.]
Deposited On:24 Apr 2013 12:39

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