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Ni(II) carcinogenesis and binding to Cap43 protein

Zoroddu, Maria Antonietta and Peana, Massimiliano Francesco and Medici, Serenella and Kowalik-Jankowska, Teresa and Kozlowski, Henryk and Costa, Max (2004) Ni(II) carcinogenesis and binding to Cap43 protein. In: Metals, environment, health: international symposium: book of abstracts, June 24-27, 2004, Szklarska Poreba, Poland. Wroclaw, [s.n.]. p. 32. Conference or Workshop Item.

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Abstract

Nickel compunds are well known as human carcinogens. The carcinogenity of nickel compounds has been confirmed by numerous epidemiological studies in humans and animals. The leading concepts in nickel carcinogenesis involves oxidative promutagenic DNA damage and epigenetic effects in chromatin resulting from nickel binding inside the cell nucleus.
We have analyzed, for Ni(II) binding, the 30-amino acid C-terminal fragment of the protein, by a combined pH-metric and spectroscopic study. The fragment showed to bind one, two and three metal ions depending on the metal to ligand molar ratio.

Item Type:Conference or Workshop Item (Lecture)
ID Code:8845
Status:Published
Uncontrolled Keywords:Cap43 protein, nickel compounds, carcinogenesis
Subjects:Area 03 - Scienze chimiche > CHIM/03 Chimica generale e inorganica
Divisions:001 Università di Sassari > 01 Dipartimenti > Chimica
Publisher:[s.n.]
Deposited On:22 Apr 2013 10:39

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