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Cyclopenta[e] [1,5] benzodiazepin-10 (9H)-one derivatives as CNS depressant agents

Mulè, Antonio Calogero and Pirisino, Gerolamo Antonio and Moretti, Mario Domenico Luigi and Savelli, Francesco and Boido, A. and Satta, M. and Peana, Alessandra Tiziana (1994) Cyclopenta[e] [1,5] benzodiazepin-10 (9H)-one derivatives as CNS depressant agents. Bollettino chimico farmaceutico, Vol. 133 (3), p. 167-172. ISSN 0006-6648. Article.

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A series of dialkylaminoalkyl derivatives of cyclopenta[e] [1,5] benzodiazepin-10(9H)-one (E1-4) and its 6-chloro derivative (E5-8) was prepared to evaluate their CNS activity in comparison with that of isosteric pyridodiazepinones (A1-4) previously described. The results of the pharmacological screening show a significant depressant activity more remarkable in 6-chloro derivatives, which also revealed a high and lasting analgesic activity. The replacement of pyridine with benzene nucleus did not show any significant or homogeneous activity variation.

Item Type:Article
ID Code:8832
Uncontrolled Keywords:Dialkylaminoalkyl derivatives of cyclopenta[e] [1,5] benzodiazepin-10(9H)-one (E1-4), 6-chloro derivative (E5-8), CNS activity, isosteric pyridodiazepinones (A1-4)
Subjects:Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Società Editoriale Farmaceutica
Deposited On:27 Mar 2013 14:00

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