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Synthesis and CNS activities of pyridopyrazinone and pyridodiazepinone derivatives

Savelli, Francesco and Boido, A. and Satta, M. and Peana, Alessandra Tiziana and Marzano, Cristina (1994) Synthesis and CNS activities of pyridopyrazinone and pyridodiazepinone derivatives. Il Farmaco, Vol. 49 (4), p. 259-265. ISSN 0014-827X. Article.

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New tricyclic derivatives with cyclocondensed pyrido-pyrazine 7,10 and pyrido-diazepine 20a,20b skeletons were synthetized and biologically investigated. The compounds, preliminarily tested on explorative, muscle relaxing, antinociceptive, spontaneous motor activities and influence on the narcotic effect of Evipan, revealed interesting CNS depressant and analgesic activities. The pyrido[2,3-e]pyrrolo[1,2-a]pyrazine structure of 7 appeared the most promising for analgesic and neuroleptic activities. The above compounds were assayed also for their capacity to inhibit DNA synthesis in Ehrlich ascites tumor cells; 20a appeared to be able of inducing a significant inhibition.

Item Type:Article
ID Code:8830
Uncontrolled Keywords:CNS activities, cyclocondensed pyrido-pyrazine 7,10, pyrido-diazepine 20a,20b skeletons
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Società chimica italiana
Publisher Policy:Depositato per gentile concessione dell'Editore
Deposited On:27 Mar 2013 12:13

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