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Synthesis and pharmacological activity of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones

Pinna, Gérard Aimé and Curzu, Maria Michela and Gavini, Elisabetta and Mulè, Antonio Calogero and Pirisino, Gerolamo Antonio and Satta, M. and Peana, Alessandra Tiziana (1993) Synthesis and pharmacological activity of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones. Il Farmaco, Vol. 48 (9), p. 1239-1247. ISSN 0014-827X. Article.

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A new series of 4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones 4a-g have been synthesized and tested for their anti-inflammatory and analgesic properties. Among the tested compounds, only 4f at 1 mmole/Kg showed antiinflammatory activity that was comparable with that of indomethacin (5 mg/Kg) though of shorter duration. Compounds 4a, 4e and especially 4g at 0.2 mmoles/Kg displayed relevant analgesic activity, 4g being the most potent derivative in the writhing test. Compounds 4c and 4g were found to possess analgesic activity also in the hot plate test.

Item Type:Article
ID Code:8829
Uncontrolled Keywords:4-carbamoyl-6-beta-thienyl-4,5-dihydropyridazin-3-(2H)ones, anti-inflammatory activity, analgesic properties
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Società chimica italiana
Publisher Policy:Depositato per gentile concessione dell'Editore
Additional Information:An account of this work was communicated at the "3rd International Symposium on the chemistry and pharmacology of the pyridazines"; Como, 9-11 September 1992.
Deposited On:26 Mar 2013 10:48

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