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Synthesis and pharmacological activity of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones

Pinna, Gérard Aimé and Sardu, F. and Curzu, Maria Michela and Satta, M. and Peana, Alessandra Tiziana and Cignarella, Giorgio and Barlocco, D. (1992) Synthesis and pharmacological activity of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones. Il Farmaco, Vol. 47 (4), p. 449-463. ISSN 0014-827X. Article.

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A new series of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones have been synthesized and tested for their antiinflammatory and analgesic properties. Amongst the test compounds, only 31 showed antiinflammatory activity, though of shorter duration than that of indomethacin, taken as reference drug. On the contrary, many derivatives displayed relevant analgesic activity, 4--the only 4,5-dehydroderivative--being the most potent in the writhing test. In the hot plate test 3b, 3f and 3k were found to possess the most significant analgesic properties.

Item Type:Article
ID Code:8813
Uncontrolled Keywords:4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones, antiinflammatory activity, analgesic properties
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Società chimica italiana
Deposited On:21 Mar 2013 12:00

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