titoli, abstracts, parole chiave >>>
Synthesis and pharmacological activity of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones

Pinna, Gérard Aimé and Sardu, F. and Curzu, Maria Michela and Satta, M. and Peana, Alessandra Tiziana and Cignarella, Giorgio and Barlocco, D. (1992) Synthesis and pharmacological activity of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones. Il Farmaco, Vol. 47 (4), p. 449-463. ISSN 0014-827X. Article.

Full text not available from this repository.

Alternative URLs:

Abstract

A new series of 4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones have been synthesized and tested for their antiinflammatory and analgesic properties. Amongst the test compounds, only 31 showed antiinflammatory activity, though of shorter duration than that of indomethacin, taken as reference drug. On the contrary, many derivatives displayed relevant analgesic activity, 4--the only 4,5-dehydroderivative--being the most potent in the writhing test. In the hot plate test 3b, 3f and 3k were found to possess the most significant analgesic properties.

Item Type:Article
ID Code:8813
Status:Published
Refereed:Yes
Uncontrolled Keywords:4-carbamoyl-5-aryl-6-methyl-4,5-dihydropyridazin-3(2H)-ones, antiinflammatory activity, analgesic properties
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01 Dipartimenti > Farmaco, chimico, tossicologico
Publisher:Società chimica italiana
ISSN:0014-827X
Deposited On:21 Mar 2013 12:00

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page