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Effect of simulated microgravity on PGE2-induced edema and hyperalgesia in rat paws: pharmacological data and biochemical correlates

Peana, Alessandra Tiziana and Bennardini, Federico and Buttu, Luisa and Pippia, Proto Gavino and Meloni, Maria Antonia and Stuffler, R.G. and Maccarrone, Mauro (2004) Effect of simulated microgravity on PGE2-induced edema and hyperalgesia in rat paws: pharmacological data and biochemical correlates. Journal of Gravitational Physiology, Vol. 11 (2), p. 41-42. ISSN 1077-9248. Article.

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Abstract

The aim of the present study has been to investigate the effect of conditions of modeled microgravity using a three-dimensional clinostat (Random Positioning Machine, RPM) on edema and thermal hyperalgesia induced by prostaglandin E2 (PGE2) in the hind paw of rat. Our results showed that RPM reduced PGE2-evoked edema associated to a significant decrease in hyperalgesia compared to ground control animals. To further characterize the mechanisms by which RPM induces anti-inflammatory and anti-hyperalgesic action, we performed biochemical assays of PGE2 and Western immunoblot experiments to assess whether the intraplantar administration of exogenous PGE2 modifies the expression of the iNOS. These results showed that RPM diminished the levels of PGE2 in exudates of paws previously treated with PGE2, but did not influence the iNOS expression.

Item Type:Article
ID Code:8812
Status:Published
Refereed:Yes
Uncontrolled Keywords:Random Positioning Machine (RPM), prostaglandin E2 (PGE2)
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Area 05 - Scienze biologiche > BIO/09 Fisiologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze fisiologiche, biochimiche e cellulari
001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Galileo Foundation
ISSN:1077-9248
Deposited On:21 Mar 2013 10:49

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