titoli, abstracts, parole chiave >>>
Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan

Khan, Adnan and Farooqui, Amber and Raza, Yasir and Rasheed, Faisal and Manzoor, Hamid and Akhtar, Syed Shakeel and Quraishy, Muhammad Saeed and Rubino, Salvatore and Kazmi, Shahana U. and Paglietti, Bianca (2013) Prevalence, diversity and disease association of Helicobacter pylori in dyspeptic patients from Pakistan. The Journal of Infection in Developing Countries, Vol. 7 (3), p. 220-228. eISSN 1972-2680. Article.

[img]Full text disponibile come PDF Richiede visualizzatore di PDF come GSview, Xpdf o Adobe Acrobat Reader
Available under License Creative Commons Attribution.

726Kb

DOI: 10.3855/jidc.2942

Abstract

Introduction: The etiological association of Helicobacter pylori with gastric ulcer (GU), gastric cancer (GC), and duodenal ulcer (DU) is well-known. Understanding the epidemiology of H. pylori facilitates the estimation of disease burden in a certain population. This study presents the diversity of H. pylori genotypes and their association with different clinical outcomes among dyspeptic patients in Pakistan over a period of four years.
Methodology: Gastric biopsy samples from a total of 450 dyspeptic individualswere subjected to PCR, genotypingand histology.
Results: A total of 201 (45%) cases were found positive for H. pylori. The detection rate was high in GU (91%), DU (86%) and GC (83%) cases compared with those cases who had intact gastric mucosa (18%). Histology revealed the presence of infection in 68% of cases of mild/chronic nonspecific gastritis with others belonging to the GU sequel. cagA gene carriage was observed in 104 (51%) cases or mostly from DU, GU and GC groups, of which 97 were Western type strains while 3 were East-Asian type strains that are rarely observed in South Asia. vacA allelic variant s1am1 was most commonly observed, followed by s1am2, and s1bm1, with direct correlation in diseased cases (gastritis, GU, DU and GC). Prevalent genotypic combinations were s1am1/cagA- in gastritis and s1am1/cagA+ in DU, GU, and GC.
Conclusions: Our study indicates the predominant circulation of Western type cagA and vacAs1am1 type H. pylori strains in Pakistan.

Item Type:Article
ID Code:8804
Status:Published
Refereed:Yes
Uncontrolled Keywords:H. pylori, cagA, vacA, duodenal ulcer, gastric ulcer, Pakistan
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 02 Centri > Centro di eccellenza interdisc. sviluppo ricerca biotecnologica e studio biodiversità della Sardegna e dell'area mediterranea
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:OLoeP
eISSN:1972-2680
Copyright Holders:© 2013 Khan et al.
Deposited On:20 Mar 2013 17:14

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page