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Age, scrapie status, PrP genotype and follicular dendritic cells in ovine ileal Peyer’s patches

Marruchella, Giuseppe and Ligios, Ciriaco and Di Guardo, Giovanni (2012) Age, scrapie status, PrP genotype and follicular dendritic cells in ovine ileal Peyer’s patches. Research In Veterinary Science, Vol. 93 (2), p. 853-856. eISSN 1532-2661. Article.

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DOI: 10.1016/j.rvsc.2011.09.002


Follicular dendritic cells (FDCs) residing within ileal Peyer’s patches (PPs) are of crucial relevance for sheep scrapie early pathogenesis and subsequent scrapie prion neuroinvasion. In this study, ileal PP follicles were significantly more numerous in lambs than in adult Sarda breed sheep, with significant differences being also found in lymphoid follicle area, perimeter and FDC density. Furthermore, PrPd deposition within ileal PPs and host’s PrP genotype did not significantly influence these parameters. We conclude that age significantly affects FDC density in ileal PPs from Sarda breed ovines, independently from host’s scrapie status and PrP genotype.

Item Type:Article
ID Code:8776
Uncontrolled Keywords:Sheep, scrapie, follicular dendritic cells, Ileal Peyer’s patches, age, PrP genotype
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/03 Patologia generale e anatomia patologica veterinaria
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Istituto zooprofilattico sperimentale della Sardegna, Sassari
Copyright Holders:© 2011 Elsevier Ltd.
Deposited On:08 Mar 2013 11:04

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