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Nanoformulation of natural products for prevention and therapy of prostate cancer

Sanna, Vanna and Siddiqui, Imtiaz A. and Sechi, Mario and Mukhtar, Hasan (2013) Nanoformulation of natural products for prevention and therapy of prostate cancer. Cancer Letters, Vol. 334 (1), p. 142-151. eISSN 1872-7980. Article.

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DOI: 10.1016/j.canlet.2012.11.037


There is a need for developing improved therapeutic options for the management of prostate cancer, able to inhibit proliferation of precancerous and malignant lesions and/or to improve the effectiveness of conventional chemopreventive and chemotherapeutic agents. In this perspective, application of nanotechnology based strategies for the delivery of natural compounds for effective management of the disease is being actively researched. Here, after highlighting the most promising natural compounds for chemoprevention and chemotherapy of prostate cancer, the state of the art nanotherapeutics and the recent proof-of-concept of “nanochemoprevention”, as well as the clinical development of promising targeted nanoprototypes for use in the prostate cancer treatment are being discussed.

Item Type:Article
ID Code:8771
Uncontrolled Keywords:Prostate cancer, natural products, nanoparticles, PSMA, nanochemoprevention, targeted nanoparticles
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Deposited On:07 Mar 2013 10:56

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