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Evaluation of the effect of hydroxypropyl-β-cyclodextrin on topical administration of milk thistle extract

Spada, Gianpiera and Gavini, Elisabetta and Cossu, Massimo and Rassu, Giovanna and Carta, Antonio and Giunchedi, Paolo (2013) Evaluation of the effect of hydroxypropyl-β-cyclodextrin on topical administration of milk thistle extract. Carbohydrate polymers, Vol. 92 (1), p. 40-47. eISSN 1879-1344. Article.

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DOI: 10.1016/j.carbpol.2012.09.018

Abstract

Two water in oil emulsions composed by eudermic ingredients as glycerin, cocoa butter, almond oil and a variety of lipids, were enriched respectively with milk thistle dry extract (MT) or with a binary complex composed by MT and hydroxypropyl-β-cyclodextrin (HP) (1:4 w/w) correspondent to 1% (w/w) in sylimarine in order to obtain two different emulsions designed for the skin delivery and determine influence of hydroxypropyl-β-cyclodextrin on the extract delivery and permeation. Uv–vis spectrophotometric analyses demonstrated that phytocomplex formation influences the finding of MT after the complexation process and the in vitro antioxidant activity. Further in vitro and ex vivo experiments demonstrated that the penetration capability of MT from formulations is strictly influenced by the phytocomplex able to control MT permeation; moreover phytocomplex increases flavonoids stability during the in vitro tests. Additionally, in vivo studies showed that the penetration into the stratum corneum of the active ingredients is effectively achieved by the phytocomplex formation, in fact about 80% of MT is absorbed by the skin along 1 h despite the 30% of MT not complexed absorbed during the same period.

Item Type:Article
ID Code:8749
Status:Published
Refereed:Yes
Uncontrolled Keywords:Hydroxypropyl-β-cyclodextrin, skin delivery, milk thistle dry extract, silymarine, antioxidant activity
Subjects:Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Elsevier
eISSN:1879-1344
Copyright Holders:© 2012 Elsevier
Deposited On:05 Mar 2013 09:43

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