Fozza, Claudio and Longinotti, Maurizio Roberto (2013) The Role of T-cells in the pathogenesis of myelodysplastic syndromes: passengers and drivers. Leukemia Research, Vol. 37 (2), p. 201-203. eISSN 1873-5835. Article.
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Although a burden of clinical and experimental data suggest the involvement of T-lymphocytes in the pathogenesis of myelodysplastic syndromes (MDS), the actual weight exerted by T-cells in this scenario is yet to be conclusively dissected. This brief review will try to further address this point, by running through the most relevant studies exploring the T-cell repertoire of MDS patients as well as the potential role of specific T-cell subsets such as regulatory T-cells and Th17 T-cells.
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