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The Role of T-cells in the pathogenesis of myelodysplastic syndromes: passengers and drivers

Fozza, Claudio and Longinotti, Maurizio Roberto (2013) The Role of T-cells in the pathogenesis of myelodysplastic syndromes: passengers and drivers. Leukemia Research, Vol. 37 (2), p. 201-203. eISSN 1873-5835. Article.

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DOI: 10.1016/j.leukres.2012.11.007

Abstract

Although a burden of clinical and experimental data suggest the involvement of T-lymphocytes in the pathogenesis of myelodysplastic syndromes (MDS), the actual weight exerted by T-cells in this scenario is yet to be conclusively dissected. This brief review will try to further address this point, by running through the most relevant studies exploring the T-cell repertoire of MDS patients as well as the potential role of specific T-cell subsets such as regulatory T-cells and Th17 T-cells.

Item Type:Article
ID Code:8748
Status:Published
Refereed:Yes
Uncontrolled Keywords:Myelodysplastic syndromes, T-cells, T-cell receptor repertoire, regulatory T cells
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier Science
eISSN:1873-5835
Copyright Holders:© 2012 Elsevier Ltd.
Deposited On:04 Mar 2013 18:32

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