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The Role of memantine in the treatment of psychiatric disorders other than the dementias

Sani, Gabriele and Serra, Giulia and Kotzalidis, Georgios D. and Romano, Silvia and Tamorri, Stefano Maria and Manfredi, Giovanni and Caloro, Matteo and Telesforo, C. Ludovica and Caltagirone, Saverio Simone and Panaccione, Isabella and Simonetti, Alessio and Demontis, Francesca and Serra, Gino and Girardi, Paolo (2012) The Role of memantine in the treatment of psychiatric disorders other than the dementias. CNS drugs, Vol. 26 (8), p. 663-690. eISSN 1179-1934. Article.

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DOI: 10.2165/11634390-000000000-00000

Abstract

Memantine, a non-competitive NMDA receptor antagonist approved for Alzheimer’s disease with a good safety profile, is increasingly being studied in a variety of non-dementia psychiatric disorders. We aimed to critically review relevant literature on the use of the drug in such disorders. We performed a PubMed search of the effects of memantine in animal models of psychiatric disorders and its effects in human studies of specific psychiatric disorders. The bulk of the data relates to the effects of memantine in major depressive disorder and schizophrenia, although more recent studies have provided data on the use of the drug in bipolar disorder as an add-on. Despite interesting preclinical data, results in major depression are not encouraging. Animal studies investigating the possible usefulness of memantine in schizophrenia are controversial; however, interesting findings were obtained in open studies of schizophrenia, but negative placebo-controlled, double-blind studies cast doubt on their validity. The effects of memantine in anxiety disorders have been poorly investigated, but data indicate that the use of the drug in obsessive-compulsive disorder and post-traumatic stress disorder holds promise, while findings relating to generalized anxiety disorder are rather disappointing. Results in eating disorders, catatonia, impulse control disorders (pathological gambling), substance and alcohol abuse/dependence, and attention-deficit hyperactivity disorder are inconclusive. In most psychiatric non-Alzheimer’s disease conditions, the clinical data fail to support the usefulness of memantine as monotherapy or add-on treatment However, recent preclinical and clinical findings suggest that add-on memantine may show antimanic and mood-stabilizing effects in treatment-resistant bipolar disorder.

Item Type:Article
ID Code:8704
Status:Published
Refereed:Yes
Uncontrolled Keywords:Memantine, non-dementia psychiatric disorders (NDPD), results
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Springer
eISSN:1179-1934
Copyright Holders:Adis © 2012 Springer International Publishing
Deposited On:27 May 2013 13:35

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