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Nanoparticle therapeutics for prostate cancer treatment

Sanna, Vanna and Sechi, Mario (2012) Nanoparticle therapeutics for prostate cancer treatment. Nanomedicine: Nanotechnology, Biology and Medicine, Vol. 8 (Suppl. 1), S31-S36. eISSN 1549-9642. Article.

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DOI: 10.1016/j.nano.2012.05.009

Abstract

The application of nanotechnology in medicine is offering many exciting possibilities in healthcare. Engineered nanoparticles have the potential to revolutionize the diagnosis and the therapy of several diseases, particularly by targeted delivery of anticancer drugs and imaging contrast agents. Prostate cancer, the second most common cancer in men, represents one of the major epidemiological problems, especially for patients in the advanced age. There is a substantial interest in developing therapeutic options for treatment of prostate cancer based on use of nanodevices, to overcome the lack of specificity of conventional chemotherapeutic agents as well as for the early detection of precancerous and malignant lesions. Herein, we highlight on the recent development of nanotechnology strategies adopted for the management of prostate cancer. In particular, the combination of targeted and controlled-release polymer nanotechnologies has recently resulted in the clinical development of BIND-014, a promising targeted Docetaxel-loaded nanoprototype, which can be validated for use in the prostate cancer therapy. However, several limitations facing nanoparticle delivery to solid tumours, such as heterogeneity of intratumoural barriers and vasculature, cytotoxicity and/or hypersensitivity reactions to currently available cancer nanomedicines, and the difficult in developing targeted nanoparticles with optimal biophysicochemical properties, should be still addressed for a successful tumour eradication.

Item Type:Article
ID Code:8700
Status:Published
Refereed:Yes
Uncontrolled Keywords:Prostate cancer, nanoparticles, targeted nanoparticles, diagnosis, theranostic
Subjects:Area 03 - Scienze chimiche > CHIM/08 Chimica farmaceutica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Porto Conte Ricerche, Alghero
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Elsevier
eISSN:1549-9642
Deposited On:26 Feb 2013 11:09

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