titoli, abstracts, parole chiave >>>
Possible role of dopamine D1-like and D2-like receptors in behavioural activation and evaluation of response efficacy in the forced swimming test

D'Aquila, Paolo Stefano and Galistu, Adriana (2012) Possible role of dopamine D1-like and D2-like receptors in behavioural activation and evaluation of response efficacy in the forced swimming test. Neuropharmacology, Vol. 62 (4), p. 1717-1729. eISSN 1873-7064. Article.

Full text not available from this repository.

DOI: 10.1016/j.neuropharm.2011.11.018

Abstract

Based on the different effects of the dopamine D1-like and D2-like receptor antagonists SCH 23390 and raclopride on the measures of licking microstructure in rats ingesting a sucrose solution, we suggested that the behavioural activation of reward-associated responses depends on dopamine D1-like receptor stimulation, and its level is updated, or “reboosted”, on the basis of a dopamine D2-like receptor-mediated evaluation process. The aim of this study was to test this hypothesis on the forced swimming test response. The effects of the dopamine D1-like and D2-like receptor antagonists SCH 23390 (0.01–0.04 mg/kg) and raclopride (0.025–0.25 mg/kg) administered before a 15-min exposure to forced swimming, and the response to a second session performed 24 h later, were examined. SCH 23390 dose-dependently reduced climbing scores in the first session and increased them in the second session, but the within-session decline of this measure was similar to that observed in the control group in both sessions. Raclopride-treated subjects showed a slightly reduced level of climbing scores at the beginning of the first session, but persisted in emitting this costly behavioural response up to the end of the session, while no effects were observed in the second session. These results, along with our results examining licking for sucrose, are consistent with the hypothesis that behavioural activation and response effort allocation are directly mediated by dopamine D1-like receptor stimulation, but the level of this activation is updated, or “reboosted”, on the basis of a dopamine D2-like receptor-mediated mechanism of response efficacy evaluation.

Item Type:Article
ID Code:8668
Status:Published
Refereed:Yes
Uncontrolled Keywords:Dopamine receptor, dopamine, activation, response effort allocation, response efficacy, evaluation
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
002 Altri enti e centri di ricerca del Nord Sardegna > Istituto nazionale biostrutture e biosistemi, Unità di ricerca, Sassari
Publisher:Elsevier Science
eISSN:1873-7064
Copyright Holders:© 2011 Elsevier Ltd.
Deposited On:21 Feb 2013 13:47

I documenti depositati in UnissResearch sono protetti dalle leggi che regolano il diritto d'autore

Repository Staff Only: item control page