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Cyclopentenyl ethylamines active on CNS

Mulè, Antonio Calogero and Pirisino, Gerolamo Antonio and Moretti, Mario Domenico Luigi and Sparatore, Fabio and Dimich, P.M. and Satta, Margherita and Peana, Alessandra Tiziana (1992) Cyclopentenyl ethylamines active on CNS. Il Farmaco, Vol. 47 (9), p. 1161-1172. ISSN 0014-827X. Article.

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Abstract

Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic activity. Compound 5, bearing a phenyl group on the carbon atom to which the amino group is connected, appears rather interesting being the most active as analgesic and the least toxic. Compounds 2 and 3 are able to antagonize in a certain degree lethal doses of physostigmine and also, respectively, of pentylenetetrazole and strychnine.

Item Type:Article
ID Code:8664
Status:Published
Refereed:Yes
Uncontrolled Keywords:Cyclopentenylethylamines, CNS, analgesic activity
Subjects:Area 03 - Scienze chimiche > CHIM/09 Farmaceutico tecnologico applicativo
Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze del farmaco
Publisher:Società chimica italiana
ISSN:0014-827X
Publisher Policy:Depositato per gentile concessione dell'Editore
Deposited On:21 Feb 2013 11:23

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