Mulè, Antonio Calogero and Pirisino, Gerolamo Antonio and Moretti, Mario Domenico Luigi and Sparatore, Fabio and Dimich, P.M. and Satta, Margherita and Peana, Alessandra Tiziana (1992) Cyclopentenyl ethylamines active on CNS. Il Farmaco, Vol. 47 (9), p. 1161-1172. ISSN 0014-827X. Article.
Two new cyclopentenylethylamines were prepared and were submitted to a pharmacological screening together with some others previously described and now reprepared. All compounds exhibited different degrees of depressive activity on CNS and good analgesic activity. Compound 5, bearing a phenyl group on the carbon atom to which the amino group is connected, appears rather interesting being the most active as analgesic and the least toxic. Compounds 2 and 3 are able to antagonize in a certain degree lethal doses of physostigmine and also, respectively, of pentylenetetrazole and strychnine.
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