Madeddu, Paolo Roberto and Glorioso, Nicola and Soro, Aldo and Tonolo, Giancarlo and Manunta, Paolo and Troffa, Chiara and Demontis, Maria Piera and Varoni, Maria Vittoria and Anania, Vittorio Domenico (1990) Brain kinins are responsible for the pressor effect of intracerebroventricular captopril in spontaneously hypertensive rats. Hypertension, Vol. 15 (4), p. 407-412. eISSN 1524-4563. Article.
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The role of the brain kallikrein-kinin system in the regulation of arterial blood pressure of normotensive and spontaneously hypertensive rats was evaluated. Intracerebroventricular administration of the kinin antagonist [DArg°]Hyp3-Thi5'8[DPhe7] bradykinin caused no change in mean blood pressure in Wistar-Kyoto, Sprague-Dawley, or spontaneously hypertensive rats. The antagonist proved to be very potent in blocking the pressor effect of intracerebroventricular bradykinin (32±3 vs. 3±1 mm Hg,p<0.01). It was specific, as the pressor effect induced by other unrelated peptides was similar during the infusion of either vehicle or kinin antagonist (angiotensin II, 25±4 vs. 26±2 mm Hg; prostaglandin E2, 48±3 vs. 47±8 mm Hg; norepinephrine, 17±2 vs. 18±2 mm Hg; leucine-enkephaline, 15±2 vs. 16±1 mm Hg; neurotensin, 18±2 vs. 19±1 mm Hg; substance P, 19±2 vs. 19±2 mm Hg). Intracerebroventricular administration of 1 mg captopril, an inhibitor of kininase II (one of the enzymes responsible for kinin degradation), caused no change in mean blood pressure in normotensive rats, whereas it increased mean blood pressure by 44±9 mm Hg (p<0.01) in spontaneously hypertensive rats. This increase in mean blood pressure was blocked and then reversed into a hypotensive effect (22 ±6 mm Hg, p<0.05) during the infusion of kinin antagonist. Our data suggest that the pressor effect induced by intracerebroventricular captopril is due to a transient elevation in endogenous brain kinin levels, supporting the hypothesis that the brain kallikrein-kinin system plays a role in the central regulation of blood pressure in spontaneously hypertensive rats.
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