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Effect of L-cysteine on acetaldehyde self-administration

Peana, Alessandra Tiziana and Muggironi, Giulia and Fois, Giulia R. and Zinellu, Manuel and Sirca, Donatella (2012) Effect of L-cysteine on acetaldehyde self-administration. Alcohol, Vol. 46 (5), p. 489-497. eISSN 1873-6823. Article.

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DOI: 10.1016/j.alcohol.2011.10.004

Abstract

Acetaldehyde (ACD), the first metabolite of ethanol, has been implicated in several behavioural actions of alcohol, including its reinforcing effects. Recently, we reported that L-cysteine, a sequestrating agent of ACD, reduced oral ethanol self-administration and that ACD was orally self-administered. This study examined the effects of L-cysteine pre-treatment during the acquisition and maintenance phases of ACD (0.2%) self-administration as well as on the deprivation effect after ACD extinction and on a progressive ratio (PR) schedule of reinforcement. In a separate PR schedule of reinforcement, the effect of L-cysteine was assessed on the break-point produced by ethanol (10%). Furthermore, we tested the effect of L-cysteine on saccharin (0.2%) reinforcement. Wistar rats were trained to self-administer ACD by nose poking on a fixed ratio (FR1) schedule in 30-min daily sessions. Responses on an active nose-poke caused delivery of ACD solution, whereas responses on an inactive nose-poke had no consequences. L-cysteine reduced the acquisition (40 mg/kg), the maintenance and the deprivation effect (100 mg/kg) of ACD self-administration. Furthermore, at the same dose, L-cysteine (120 mg/kg) decreased both ACD and ethanol break point. In addition, L-cysteine was unable to suppress the different responses for saccharin, suggesting that its effect did not relate to an unspecific decrease in a general motivational state. Compared to saline, L-cysteine did not modify responses on inactive nose-pokes, suggesting an absence of a non-specific behavioural activation. Taken together, these results could support the hypotheses that ACD possesses reinforcing properties and L-cysteine reduces motivation to self-administer ACD.

Item Type:Article
ID Code:8648
Status:Published
Refereed:Yes
Uncontrolled Keywords:ACD self-administration, ethanol, L-cysteine, rat
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Chimica e Farmacia
Publisher:Elsevier
eISSN:1873-6823
Deposited On:20 Feb 2013 14:53

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