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Regulatory T cells in stem cell transplantation: main characters or walk-on actors?

Fozza, Claudio and Dazzi, Francesco (2012) Regulatory T cells in stem cell transplantation: main characters or walk-on actors? Critical reviews in oncology/hematology, Vol. 84 (1), p. 18-25. eISSN 1879-0461. Article.

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DOI: 10.1016/j.critrevonc.2012.02.003

Abstract

Almost 10 years have passed since the first experiments specifically addressing the role of regulatory T cells (Treg) in stem cell transplantation (SCT). It is now time to try to dissect what is their actual impact in such a therapeutic context. In the present review we will initially remind the preliminary experiments exploring the Treg behavior in murine models of SCT, then moving to the first studies evaluating their influence on graft versus host disease and graft versus leukemia in humans. After focusing on some interesting aspects of Treg mechanisms of action after SCT, we will evaluate their activity after donor lymphocyte infusion as well as after reduced intensity conditioning and autologous SCT. We will conclude by briefly discussing possible therapeutic applications of Treg and highlighting biological and clinical issues which deserve to be further assessed in the next future.

Item Type:Article
ID Code:8641
Status:Published
Refereed:Yes
Uncontrolled Keywords:Regulatory T cells, stem cell transplantation, graft versus host disease, graft versus leukemia
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier Science
eISSN:1879-0461
Deposited On:19 Feb 2013 13:48

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