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T-cell receptor repertoire usage in hematologic malignancies

Fozza, Claudio and Longinotti, Maurizio Roberto (2013) T-cell receptor repertoire usage in hematologic malignancies. Critical reviews in oncology/hematology, Vol. 86 (3), p. 201-211. eISSN 1879-0461. Article.

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DOI: 10.1016/j.critrevonc.2012.11.005

Abstract

Over the last few years several studies have addressed the possible influence of different immune mechanisms on the evolution of hematologic malignancies. More specifically, a fundamental role of reactive T-cells has now been demonstrated in the pathogenesis of many of these disorders as well as in the typical immunological milieu observed after stem cell transplantation in patients affected by these malignancies. In this context the study of the T-cell receptor (TCR) repertoire performed by different techniques, such as for instance flow cytometry and spectratyping, has undoubtedly provided a fundamental contribution. More recently, these seminal observations have even opened new potential therapeutic avenues based on the employment of adoptive T-cells somehow engineered toward potential neoplastic targets. This review will run through the most relevant studies which have tried to dissect the TCR repertoire usage in patients with different hematologic malignancies, especially focusing on the possible pathogenetic and therapeutic implications.

Item Type:Article
ID Code:8639
Status:Published
Refereed:Yes
Uncontrolled Keywords:T-cell receptor (TCR) repertoire, hematologic malignancies, CDR3 spectratyping, flow cytometry
Subjects:Area 06 - Scienze mediche > MED/15 Malattie del sangue
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier Science
eISSN:1879-0461
Deposited On:19 Feb 2013 12:51

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