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Possible role of dopamine D1-like and D2-like receptors in behavioural activation and “contingent” reward evaluation in sodium-replete and sodium-depleted rats licking for NaCl solutions

D'Aquila, Paolo Stefano and Rossi, Roberta and Rizzi, Antonella and Galistu, Adriana (2012) Possible role of dopamine D1-like and D2-like receptors in behavioural activation and “contingent” reward evaluation in sodium-replete and sodium-depleted rats licking for NaCl solutions. Pharmacology, biochemistry and behavior, Vol. 101 (1), p. 99-106. eISSN 1873-5177. Article.

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DOI: 10.1016/j.pbb.2011.12.004

Abstract

Based on the different effects of the dopamine D1-like and D2-like receptor antagonists SCH 23390 and raclopride on the measures of licking microstructure in rats, we suggested that the level of activation of reward-associated responses depends on dopamine D1-like receptor stimulation, and is updated, or “reboosted”, on the basis of a dopamine D2-like receptor-mediated reward evaluation. To further test this hypothesis, we examined the effects of the dopamine D2-like receptor antagonist raclopride (0, 25, 125, 250 μg/kg) and of the dopamine D1-like receptor antagonist SCH 23390 (0, 10, 20 and 40 μg/kg) on the microstructure of licking for two different NaCl solutions (0.9% and 2.7%) in rats in sodium-replete status and in the sodium-depleted status induced by the diuretic drug furosemide. Rats were exposed to each solution for 180 seconds after the first lick. Both in sodium-replete and in sodium-depleted status, SCH 23390 produced a decrease of burst number, a measure of behavioural activation, without affecting their size, a measure of reward evaluation. Raclopride reduced burst number but appeared also to exert some effects on burst size. Sodium depletion resulted in an increased intake for both NaCl solutions due to an increase in burst number and size, and in a reduced sensitivity to the effect of raclopride on lick number. These results are not in contrast with the proposed hypothesis and are consistent with previous evidence suggesting a role for dopamine D2-like receptors in the increased NaCl appetite induced by sodium depletion.

Item Type:Article
ID Code:8635
Status:Published
Refereed:Yes
Uncontrolled Keywords:Reward, dopamine receptor, dopamine, motivation, sodium depletion, activation
Subjects:Area 05 - Scienze biologiche > BIO/14 Farmacologia
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
002 Altri enti e centri di ricerca del Nord Sardegna > Istituto nazionale biostrutture e biosistemi, Unità di ricerca, Sassari
Publisher:Elsevier
eISSN:1873-5177
Copyright Holders:© 2011 Elsevier Inc.
Deposited On:19 Feb 2013 09:28

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