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A Population-based study of an Italian genetic isolate reveals that mean platelet volume is not a risk factor for thrombosis

Biino, Ginevra and Portas, Laura and Murgia, Federico and Vaccargiu, Simona and Parracciani, Debora and Pirastu, Mario and Balduini, Carlo L. (2012) A Population-based study of an Italian genetic isolate reveals that mean platelet volume is not a risk factor for thrombosis. Thrombosis research, Vol. 129 (4), e8-e13. eISSN 1879-2472. Article.

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DOI: 10.1016/j.thromres.2011.11.018

Abstract

Introduction: Several studies revealed that mean platelet volume (MPV) was larger in the acute phase of arterial and venous thrombosis and predicted a poor clinical outcome. It has been suggested that MPV is a risk factor for thrombosis. However, it is unclear whether increased platelet size is a cause or a consequence of thrombosis.
It was the objective of this study to verify whether MPV is a risk factor for arterial and venous thrombosis.
Methods: We search for associations between platelet parameters and thrombosis by a population-based study in 11,084 inhabitants of an Italian genetic isolate characterized by wide variability of platelet parameters. To validate this methodology of investigation, we also evaluated whether it was able to identify several well known thrombotic risk factors in the study population.
Results: Statistical analysis confirmed that male gender, ageing, hypertension, high total cholesterol, low HDL cholesterol, diabetes, obesity and smoking were risk factors for arterial thrombosis, while alcohol consumption had a protective effect. Female gender, ageing, pregnancy, estroprogestinic treatment, obesity, varicose veins were associated with venous thrombosis. At variance, MPV and platelet count were unrelated to previous thrombotic events. However, MPV was negatively correlated with the time since the last thrombotic event.
Conclusions: This study indicated that an epidemiologic study of a population isolate is appropriate for the identification of thrombotic risk factors, but it failed to identify such a role for MPV. Thus, we suggest that the increased MPV previously described in subjects with acute thrombosis was a consequence instead of a cause of thrombosis.

Item Type:Article
ID Code:8595
Status:Published
Refereed:Yes
Uncontrolled Keywords:Epidemiologic study, arterial thrombosis, venous thrombosis, mean platelet volume, risk factors
Subjects:Area 05 - Scienze biologiche > BIO/18 Genetica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > CNR-Consiglio Nazionale delle Ricerche > Istituto di genetica delle popolazioni, Alghero
Publisher:Elsevier Science
eISSN:1879-2472
Copyright Holders:© 2011 Elsevier Ltd.
Deposited On:04 Feb 2013 15:49

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