Vitale, Gabriella and Corona, Paola and Loriga, Mario and Carta, Antonio and Paglietti, Giuseppe and Giliberti, Gabriele and Sanna, Giuseppina and Farci, Pamela and Marongiu, Maria Elena and La Colla, Paolo (2012) 5-Acetyl-2-arylbenzimidazoles as antiviral agents: part 4. European Journal of Medicinal Chemistry, Vol. 53 , p. 83-97. eISSN 1768-3254. Article.
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Within a project aimed at discovering new Flaviviridae inhibitors, new variously substituted 2-phenylbenzimidazoles were synthesized and evaluated in cell-based assays for cytotoxicity and antiviral activity against viruses representatives of the three genera of the Flaviviridae family, i.e.: Pestivirus (BVDV), Flavivirus (YFV) and Hepacivirus (HCV). Title compounds were also tested against RNA viruses representative of other single-stranded, positive-sense (ssRNA+) negative-sense (RNA−), or double-stranded (dsRNA) genomes, as well as against representatives of two DNA virus families.
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