Meloni, Antonella and Positano, Vincenzo and Keilberg, Petra and De Marchi, Daniele and Pepe, Pasquale and Zuccarelli, Angelo and Campisi, Saveria and Romeo, Maria Antonietta and Casini, Tommaso and Bitti, Pier Paolo and Gerardi, Calogera and Lai, Maria Eliana and Piraino, Basilia and Giuffrida, Gaetano and Secchi, Giuseppina and Midiri, Massimo and Lombardi, Massimo and Pepe, Alessia (2012) Feasibility, reproducibility, and reliability for the T*2 iron evaluation at 3 T in comparison with 1.5 T. Magnetic Resonance in Medicine, Vol. 68 (2), p. 543-551. eISSN 1522-2594. Article.
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This study aimed to determine the feasibility, reproducibility, and reliability of the multiecho T*2 Magnetic resonance imaging technique at 3 T for myocardial and liver iron burden quantification and the relationship between T*2 values at 3 and 1.5 T. Thirty-eight transfusion-dependent patients and 20 healthy subjects were studied. Cardiac segmental and global T*2 values were calculated after developing a correction map to compensate the artifactual T*2 variations. The hepatic T*2 value was determined over a region of interest. The intraoperator and interoperator reproducibility for T*2 measurements at 3 T was good. A linear relationship was found between patients' R (1000/T*2) values at 3 and 1.5 T. Segmental correction factors were significantly higher at 3 T. A conversion formula returning T*2 values at 1.5 T from values at 3 T was proposed. A good diagnostic reliability for T*2 assessment at 3 T was demonstrated. Lower limits of normal for 3 T T*2 values were 23.3 ms, 21.1 ms, and 11.7 ms, for the global heart, mid-ventricular septum, and liver, respectively. In conclusion, T*2 quantification of iron burden in the mid-ventricular septum, global heart, and no heavy–moderate livers resulted to be feasible, reproducible, and reliable at 3 T. Segmental heart T*2 analysis at 3 T may be challenging due to significantly higher susceptibility artifacts. Magn Reson Med, 2012.
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