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Increased frequencies of pulmonary regulatory T-cells in latent Mycobacterium tuberculosis infection

Herzmann, Christian and Ernst, Martin and Ehlers, Stefan and Stenger, Steffen and Maertzdorf, Jeroen and Sotgiu, Giovanni and Lange, Christoph (2012) Increased frequencies of pulmonary regulatory T-cells in latent Mycobacterium tuberculosis infection. European Respiratory Journal, Vol. 40 (6), p. 1450-1457. eISSN 1399-3003. Article.

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DOI: 10.1183/09031936.00214611

Abstract

Regulation of specific immune responses following exposure to Mycobacterium tuberculosis in humans and the role of regulatory T (Treg) cells in the immune control of latent infection with M. tuberculosis are incompletely understood.
Latent infection was assayed by an interferon-γ release assay (IGRA) in healthcare workers regularly exposed to tuberculosis (TB) patients and in household TB contacts in Germany. Immunophenotypes of bronchoalveolar lavage (BAL) mononuclear cells and peripheral blood mononuclear cells (PBMCs) were analysed by fluorescence-activated cell sorting.
All TB contacts with latent infection (n=15) had increased (p<0.0001) frequencies of CD4+ CD25+ CD127- Treg cells (median 2.12%, interquartile range (IQR) 1.63–3.01%) among BAL mononuclear cells compared with contacts (n=25) with negative IGRA results (median 0.68%, IQR 0.32–0.96%) No differences were seen when PBMC immunophenotypes of IGRA+ and IGRA- TB contacts were compared (IGRA+ median 9.6%, IQR 5.9–10.1%; IGRA- median 7.7%, IQR 4.6–11.3%; p=0.47). Five out of 25 contacts with negative blood IGRAs showed a positive IGRA from BAL cells, possibly indicating a limited local immune response.
In Germany, latent infection with M. tuberculosis, as defined by a positive M. tuberculosis-specific IGRA response on cells from the peripheral blood, is characterised by an increased frequency of Treg cells in the BAL.

Item Type:Article
ID Code:8510
Status:Published
Refereed:Yes
Uncontrolled Keywords:Treg cells, Mycobacterium tuberculosis, interferon-γ release assay (IGRA)
Subjects:Area 06 - Scienze mediche > MED/01 Statistica medica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:European Respiratory Society
eISSN:1399-3003
Deposited On:09 Jan 2013 10:54

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