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A Single nucleotide polymorphism in the promoter region of river buffalo stearoyl CoA desaturase gene (SCD) is associated with milk yield

Pauciullo, Alfredo and Cosenza, Gianfranco and Steri, Roberto and Coletta, Angelo and La Battaglia, Antonio and Di Berardino, Dino and Macciotta, Nicolò Pietro Paolo and Ramunno, Luigi (2012) A Single nucleotide polymorphism in the promoter region of river buffalo stearoyl CoA desaturase gene (SCD) is associated with milk yield. Journal of Dairy Research, Vol. 79 (4), p. 429-435. eISSN 1469-7629. Article.

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DOI: 10.1017/S0022029912000507

Abstract

An association study between the milk yield trait and the stearoyl-CoA desaturase (SCD) polymorphism (g.133A > C) in Italian Mediterranean river buffalo was carried out. A full characterization of the river buffalo SCD promoter region was presented. Genotyping information was provided and a quick method for allelic discrimination was developed. The frequency of the C allele was 0·16. Test-day (TD) records (43 510) of milk production belonging to 226 lactations of 169 buffalo cows were analysed with a mixed linear model in order to estimate the effect of g.133A > C genotype, as well as the effect of parity and calving season. The SCD genotype was significantly associated with milk yield (P = 0·02). The genotype AC showed an over-dominance effect with an average daily milk yield approximately 2 kg/d higher than CC buffaloes. Such a difference represents about 28% more milk/d. The effect of the genotype was constant across lactation stages. The contribution of SCD genotype (r 2 SCD) to the total phenotypic variance in milk yield was equal to 0·12. This report is among the first indications of genetic association between a trait of economic importance in river buffalo. Although such results need to be confirmed with large-scale studies in the same and other buffalo populations, they might offer useful indications for the application of MAS programmes in river buffalo and in the future they might be of great economic interest for the river buffalo dairy industry.

Item Type:Article
ID Code:8465
Status:Published
Refereed:Yes
Uncontrolled Keywords:Mediterranean river buffalo, stearoyl CoA desaturase gene (SCD), milk yield, marker assisted selection
Subjects:Area 07 - Scienze agrarie e veterinarie > AGR/17 Zootecnica generale e miglioramento genetico
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Agraria
Publisher:Cambridge University Press
eISSN:1469-7629
Copyright Holders:© Proprietors of Journal of Dairy Research 2012
Deposited On:12 Dec 2012 13:30

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