Abstract

Lifestyle, genetic factors and dietary habits may affect the process of healthy aging. Sardinia is known for its high incidence of centenarians. Some foods consumed by old Sardinian people (wine, cheese, fruit, vegetables, etc.) have nutraceutical and antioxidants properties that are able to maintain the integrity and physiological stability, suggesting a diet-gene interaction. By contrast, some foods may have substances with harmful properties deleterious to the body such as heavy and transition metals that can cause damages. The plasma samples analyzed came from a research project, called Akea, funded by sardianan region (LR 7/2007 and L.R. 2/2007). Wines and cheeses are all of own production while the fruit is native. From the analysis of the plasma, there was a positive correlation between Cd and Se (rs = 0.21, p <0.05) and a negative correlation between Se and drinkers (rs = -0.15, p <0.05). There were no significant differences between the levels of Cd and Se in the blood in non-smokers and smokers (p> 0.05). The plasma values of Mg, Fe, Cu, Zn and Ca in plasma are located inside the reference values, also the activity of GPX3 is normal. In food, the concentrations of Cd, Se and Pb did not exceed the maximum limits permitted by law and they appeared reassuring for the risk of contamination of the soil, water and air.

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