Farina, Donatella (2013) Studio del potenziale neuroprotettivo delle cellule staminali neurali adulte prelevate dalla zona subventricolare di topi C57BL/6, con particolare riferimento al ciclo dell’acido ascorbico. Doctoral Thesis.
Oxidative stress is widely believed an important pathogenetic mechanism of neuronal death in Parkinson's disease (PD). The subventricular zone (SVZ) in mammalian brain contains adult neural stem cells (aNSCs) that generate neurons, astrocytes and oligodendrocytes. The goal of this work was to demonstrate the antioxidant potential of aNSC, related to their ability to capture, reduce and secrete ascorbic acid (AA), an important antioxidant contained in high concentrations in the brain neurons. Another aim of this study was to identify biological structures responsible for transporting AA (SVCT2) and its oxidized form (dehydroascorbic acid, DHAA), through glucose transporters (GLUTs).
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