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Effect of lipid lowering therapy on LDL-S-homocysteinilation status in Chronic Kidney Disease patients

Pisanu, Elisabetta (2013) Effect of lipid lowering therapy on LDL-S-homocysteinilation status in Chronic Kidney Disease patients. Doctoral Thesis.

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Abstract

Chronic Kidney Disease (CKD) is currently recognized as an important global population health problem. Dyslipidemia associated with CKD contributes to the inflammatory response in renal failure. The dyslipidemia control through lipid lowering therapy is one of the targets for the treatment of CKD. The aim of this study is to evaluate the effect of hypolipidemic drugs on the LDL thiolation in proteinuric nefropatic patients during lipid lowering therapy. We enrolled thirty CKD patients randomized to receive three different hypolipidemic regimens: simvastatin alone (40 mg/day) or ezetimibe/ simvastatin combined therapy (10/20 or 10/40 mg/day). LMW thiols in their reduced and total form, oxidative stress indices as malondialdehyde and allantoin/uric acid ratio were evaluated. LDL thiolation decreased in all treated patients, but a greater efficacy was attained from a combined therapy with a higher simvastatin dose. In particular, in this patients group the reduction of apoB-Hcy was greater than 40%. The concomitant decrease of the oxidative stress indices during the therapy brings to the hypothesis that decreased levels of protein bound thiols may be a consequence of oxidative stress improvement. Therefore, among the several beneficial effects described for lipid lowering drugs we also propose their ability to reduce the quantity of LDL linked homocysteine thus decreasing not only LDL levels but also LDL atherogenicity.

Item Type:Doctoral Thesis
ID Code:8296
Contributors:Carru, Ciriaco
Publisher:Università degli studi di Sassari
Uncontrolled Keywords:Chronic Kidney Disease (CKD), LDL-S-homocysteinilation, Lipid lowering therapy
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Cicli, scuole e corsi:Ciclo 25 > Scuole > Scienze biomolecolari e biotecnologiche > Proteomica, metabolomica, biochimica clinica e biologia molecolare clinica
Deposited On:03 Apr 2013 17:05

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