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Circulating tissue kallikrein levels correlate with severity of carotid atherosclerosis

Porcu, Paolo and Emanueli, Costanza and Desortes, Elisa and Marongiu, Giovanni M. and Piredda, Franco and Chao, Lee and Chao, Julie and Madeddu, Paolo Roberto (2004) Circulating tissue kallikrein levels correlate with severity of carotid atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 24 (6), p. 1104-1110. eISSN 1524-4636. Article.

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DOI: 10.1161/01.ATV.0000128126.57688.a9

Abstract

Background— Vascular growth factors are upregulated in stroke patients, but it remains unknown if they correlate with carotid atherosclerosis.
Methods and Results— A case-control study was conducted to determine: (1) possible association between biomarkers of angiogenesis or inflammation and carotid stenosis; and (2) the impact of revascularization on the same biomarkers. Circulating vascular endothelial growth factor (VEGF), basic fibroblast GF (bFGF), tissue kallikrein (tK), and high-sensitivity C-reactive protein (hs-CRP) were measured in 89 patients with carotid obstruction and 45 age-matched controls. Patients were stratified as <50% carotid stenosis (CAS; n=16); 50% to 69% CAS (n=12); 70% to 99% CAS (n=43); and carotid occlusion (CAO; n=18). No association was found between VEGF, bFGF, or hs-CRP and obstruction grading. TK augmented from 360±30 in <50% CAS (P=NS versus controls) to 509±72 in moderate CAS (P<0.05), 1159±178 in high-grade CAS (P<0.02), and 1616±403 pg/mL in CAO (P<0.01). A threshold of 508 pg/mL provided the maximized predictive value of high-grade obstruction. After revascularization, tK decreased from 1410±352 to 782±86 pg/mL (P<0.01), whereas no change was detected in nonoperated cases. Hs-CRP was unaffected by revascularization.
Conclusions— Angiogenic factors are heterogeneously expressed in patients with carotid atherosclerosis. The tK measurement may be useful for the diagnosis and monitoring of atherosclerotic disease. A case-control study was conducted to determine possible association between biomarkers of angiogenesis or inflammation and characteristics of carotid stenosis. No association was found between circulating VEGF, bFGF, or hs-CRP and obstruction grading. Circulating tissue kallikrein increasingly augmented across categories of stenosis severity and upregulation was reversed by revascularization.

Item Type:Article
ID Code:825
Status:Published
Refereed:Yes
Uncontrolled Keywords:Growth factors, angiogenesis, atherosclerosis, inflammation, revascularization
Subjects:Area 06 - Scienze mediche > MED/22 Chirurgia vascolare
Divisions:001 Università di Sassari > 03 Istituti > Clinica medica generale e terapia medica
002 Altri enti e centri di ricerca del Nord Sardegna > National laboratory of the national institute of biostructures and biosystems, Osilo > Cardiovascular medicine and gene therapy Section
001 Università di Sassari > 03 Istituti > Clinica chirurgica generale e terapia chirurgica
Publisher:Lippincott Williams & Wilkins
eISSN:1524-4636
Copyright Holders:© American Heart Association
Deposited On:18 Aug 2009 10:03

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