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Validation of a serological test for the diagnosis of canine rickettsial disease

Masu, Gabriella and Sechi, Sara and Cocco, Raffaella and Chisu, Valentina and Tanda, Antonio and Lollai, Stefano and Masala, Giovanna (2012) Validation of a serological test for the diagnosis of canine rickettsial disease. Ticks and tick-borne diseases, Vol. 3 (5-6), p. 322-326. eISSN 1877-9603. Article.

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DOI: 10.1016/j.ttbdis.2012.10.024


Canine vector borne diseases include a variety of illnesses affecting domestic dogs worldwide. Clinical abnormalities are often nonspecific during rickettsial infections, and coinfections caused by other tick-transmitted agents may be common. The aim of this study was to validate a differential serological assay for the diagnosis of rickettsial infections by the indirect fluorescent antibody (IFA) test. Sensitivity (DSe), specificity (Dsp), accuracy (Acc), positive and negative predictive values (PPV and NPV), positive and negative likelihood ratios (LR+ and LR−), Cohen's Kappa agreement, Youden's J index and odds values were calculated in order to define the positive and negative post-test probability and to establish a link between clinical signs compatible with a rickettsial infections and serological confirmation.

Item Type:Article
ID Code:8219
Uncontrolled Keywords:Tick-borne disease, IFA, validation, sensitivity, specificity
Subjects:Area 07 - Scienze agrarie e veterinarie > VET/08 Clinica medica veterinaria
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Istituto zooprofilattico sperimentale della Sardegna, Sassari
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Medicina Veterinaria
Publisher:Elsevier / Urban und Fischer
Deposited On:26 Nov 2012 14:12

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