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FLO11 expression and lipid biosynthesis are required for air–liquid biofilm formation in a Saccharomyces cerevisiae flor strain

Zara, Giacomo and Goffrini, Paola and Lodi, Tiziana and Zara, Severino and Mannazzu, Ilaria Maria and Budroni, Marilena (2012) FLO11expression and lipid biosynthesis are required for air–liquid biofilm formation in a Saccharomyces cerevisiae flor strain. FEMS Yeast Research, Vol. 12 (7), p. 864-866. eISSN 1567-1364. Article.

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DOI: 10.1111/j.1567-1364.2012.00831.x

Abstract

Air–liquid biofilm formation is largely dependent on Flo11p and seems related to cell lipid content and composition. Here, it is shown that in the presence of cerulenin, a known inhibitor of the fatty acid synthase complex, biofilm formation is inhibited together with FLO11 transcription in a flor strain of Saccharomyces cerevisiae, while the administration of saturated fatty acids to cerulenin-containing medium restores biofilm formation and FLO11 transcription. It is also shown that, in biofilm cells, the FLO11 transcription is accompanied by the transcription of ACC1, ACS1 and INO1 key genes in lipid biosynthesis and that biofilm formation is affected by the lack of inositol in flor medium. These results are compatible with the hypothesis that the air–liquid biofilm formation depends on FLO11 transcription levels as well as on fatty acids biosynthesis.

Item Type:Article
ID Code:8126
Status:Published
Refereed:Yes
Uncontrolled Keywords:Lipid biosynthesis, FLO11, biofilm, inositol, cerulenin
Subjects:Area 07 - Scienze agrarie e veterinarie > AGR/16 Microbiologia agraria
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Agraria
Publisher:Blackwell / Wiley
eISSN:1567-1364
Copyright Holders:© 2012 Federation of European Microbiological Societies
Deposited On:09 Nov 2012 10:20

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