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Plasma taurine levels in age-related macular degeneration

Pinna, Antonio <1963- > and Zinellu, Angelo and Tendas, D. and Carru, Ciriaco (2012) Plasma taurine levels in age-related macular degeneration. Acta Ophthalmologica, Vol. 90 (Suppl. s249). eISSN 1755-3768. Article.

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DOI: 10.1111/j.1755-3768.2012.S048.x


Purpose Taurine is one of the most abundant free amino acids in many tissues, including the retina. It is a scavenger of hypochlorite and carbonyl radicals and also inhibits lipid peroxidation. Little is know about the role of taurine in the pathogenesis of AMD. The purpose of this study was to determine the plasma levels of taurine in AMD patients and in age-matched subjects without AMD.
Methods Plasma taurine levels were measured by capillary electrophoresis in 74 AMD patients (mean age: 78±6.7 years) and in 148 controls (mean age: 77±5.3 years), all accrued in September 2011-March 2012. Statistical analysis was performed using the Mann-Whitney Rank Sum Test.
Results Median taurine was 64.7 (range 28.6-127.2) µmol/L in AMD patients and 65.8 (range 28.1-132.3) µmol/L in controls. Statistical analysis showed no significant difference between the two groups.
Conclusion Results suggest that AMD patients may have similar plasma levels of taurine as matched controls without AMD. Should these results be confirmed by larger studies, this would imply that taurine may play a marginal or no role in the pathogenesis of AMD.

Item Type:Article
ID Code:8077
Uncontrolled Keywords:Taurine, plasma levels, age-related macular degeneration (AMD) patients
Subjects:Area 06 - Scienze mediche > MED/30 Malattie apparato visivo
Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Chirurgiche, Microchirurgiche e Mediche
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Blackwell / Wiley
Deposited On:22 Oct 2012 16:59

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