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Induction of Fas mediated caspase-8 independent apoptosis in immune cells by Armigeres subalbatus saliva

Liu, Shanshan and Kelvin, David J. and Leon, Alberto J. and Jin, Liqun and Farooqui, Amber (2012) Induction of Fas mediated caspase-8 independent apoptosis in immune cells by Armigeres subalbatus saliva. PLoS One, Vol. 7 (7), e41145. eISSN 1932-6203. Article.

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DOI: 10.1371/journal.pone.0041145

Abstract

Background
It is widely recognized that the introduction of saliva of bloodsucking arthropods at the site of pathogen transmission might play a central role in vector-borne infections. However, how the interaction between salivary components and the host immune system takes place and which physiological processes this leads to has yet to be investigated. Armigeres subalbatus is one of the prominent types of mosquitoes involved in the transmission of parasitic and viral diseases in humans and animals.
Methodology/Principal Findings
Using murine peritoneal macrophages and lymphocytes, and human peripheral mononuclear cells (PBMCs), this study shows that saliva of the female Ar. subalbatus induces apoptosis via interaction with the Fas receptor within a few hours but without activating caspase-8. The process further activates downstream p38 MAPK signaling, a cascade that leads to the induction of apoptosis in capase-3 dependent manner. We further illustrate that Ar. subalbatus saliva suppresses proinflammatory cytokines without changing IL-10 levels, which might happen as a result of apoptosis.
Conclusions
Our study shows for the first time that saliva-induced apoptosis is the leading phenomenon exerted by Ar. subalbatus that impede immune cells leading to the suppression of their effecter mechanism.

Item Type:Article
ID Code:8065
Status:Published
Refereed:Yes
Uncontrolled Keywords:Armigeres subalbatus, peripheral mononuclear cells (PBMCs), saliva-induced apoptosis
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Public Library of Science
eISSN:1932-6203
Copyright Holders: © 2012 Liu et al.
Deposited On:16 Oct 2012 11:39

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