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Small cell lung cancer in a young patient with osteopetrosis

Fadda, Giovanni Maria and Santeufemia, Davide Adriano and Rocca, P.C. and Costantino, Salvatore and Sanna, G. and Sarobba, Maria Giuseppa and Putzu, Carlo and Rocca, M.C. and Pinna, M.A. and Farris, Antonio (2006) Small cell lung cancer in a young patient with osteopetrosis. Tumori, Vol. 92 (6), p. 563-566. ISSN 0300-8916. eISSN 2038-2529. Article.

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Abstract

BACKGROUND: Osteopetrosis or Albers-Schönberg's disease is a heterogeneous group of rare hereditary troubles of the bone characterized by bone sclerosis due to an alteration of the bone reabsorption mediated by osteoclasts. The defect in the osteoclastic activity is responsible for complete or partial medullary cavities occlusion, with consequent reduced hemopoiesis, and for the excessive fragility of the affected bone segments.
CASE REPORT: We reported the case of a young man of 31 years affected by osteopetrosis in which a small cell lung cancer developed.
RESULTS: Small cell lung cancer is a particularly rare neoplasm in the young, and even though it is highly sensitive to chemotherapeutic treatment its prognosis remains poor. The greatest clinical problem connected with chemotherapeutic treatment of patients affected by osteopetrosis is the variability of the reduction of their bone marrow reserve, which could expose them to an excessive hematological toxicity caused by the therapy.
CONCLUSIONS: The adoption of suitable prophylactic measures, such as the use of growth factors and drugs selected in relation to their toxicity or given in reduced doses, should be appropriately considered in these subjects.

Item Type:Article
ID Code:8016
Status:Published
Refereed:Yes
Uncontrolled Keywords:Osteopetrosis, Albers-Schönberg's disease, small cell lung cancer
Subjects:Area 06 - Scienze mediche > MED/08 Anatomia patologica
Divisions:001 Università di Sassari > 01 Dipartimenti > Medicina clinica, sperimentale e oncologica
Publisher:II Pensiero scientifico editore
ISSN:0300-8916
eISSN:2038-2529
Deposited On:08 Oct 2012 09:45

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