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Low density lipoprotein S-homocysteinylation is increased in acute myocardial infarction patients

Zinellu, Angelo and Sotgia, Salvatore and Scanu, Bastianina and Deiana, Luca and Talanas, Giuseppe and Terrosu, Pier Franco and Carru, Ciriaco (2012) Low density lipoprotein S-homocysteinylation is increased in acute myocardial infarction patients. Clinical Biochemistry, Vol. 45 (4-5), p. 359-362. ISSN 0009-9120. Article.

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DOI: 10.1016/j.clinbiochem.2011.12.017

Abstract


Objectives
We have investigated on the levels of homocysteine linked to LDL in acute myocardial infarction patients.
Design and methods
We used capillary electrophoresis to measure LDL-bound thiols in 16 AMI individuals and 32 healthy volunteers.
Results
We found a significant increase of apo-B homocysteine and cysteine levels in LDL fraction of AMI subjects.
Conclusions
Our findings suggest that also LDL S-homocysteinylation may be considered among the markers for the CVD risk evaluation.

Item Type:Article
ID Code:8009
Status:Published
Refereed:Yes
Uncontrolled Keywords:Acute myocardial infarction, homocysteine, LDL, homocysteinylation, LDL-S-Hcy
Subjects:Area 05 - Scienze biologiche > BIO/12 Biochimica clinica e biologia molecolare clinica
Divisions:002 Altri enti e centri di ricerca del Nord Sardegna > Azienda ASL1, Sassari > Ospedale civile SS. Annunziata
002 Altri enti e centri di ricerca del Nord Sardegna > Porto Conte Ricerche, Alghero
001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier
ISSN:0009-9120
Deposited On:04 Oct 2012 08:37

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