Dessanti, Antonio and Di Benedetto, Vincenzo and Iannuccelli, Marco and Sanna Passino, Eraldo and Mura, Liliana and Dessanti, Giuseppina and Careddu, Giovanni Mario and Manunta, Maria Lucia Gabriella M. and Cossu Rocca, Paolo Alessandro and Sanna, Ennio (2005) Substitution of thoracic oesophagus by interposition of a pedicled gastric tube, preserving LES function: clinical and histological follow-up. Pediatric Surgery International, Vol. 21 (9), p. 705-710. eISSN 1437-9813. Article.
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Assessment of clinical evolution and histological findings in a group of animals experimentally operated on to substitute the thoracic oesophagus with a gastric tube. Six piglets underwent oesophageal replacement with a gastric tube, constructed from the greater curvature of stomach and pedicled on the gastroepiploic vessels, which was interposed between the oesophageal stumps. At follow-up, all animals were found to be growing and eating normally, apart from case no 1 (stenosis of the lower oesophageal anastomosis). Ph-metry showed a neutral pH on the gastric tube. Postmortem histological analysis of the gastric tube and native oesophagus samples did not show any significant lesions, except in case no 1 (inflammation of the gastric tube and upper oesophagus due to food stasis). The technique of substitution of the oesophagus with an interposed pedicled gastric tube can be a breakthrough in existing surgical methods of oesophageal replacement.
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