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Treatment of tuberculosis: have we turned the corner?

Migliori, Giovanni Battista and Sotgiu, Giovanni (2012) Treatment of tuberculosis: have we turned the corner? The Lancet, Vol. 380 (9846), p. 955-957. eISSN 1474-547X. Article.

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DOI: 10.1016/S0140-6736(12)61183-0

Abstract

The number of multidrug-resistant (MDR) tuberculosis cases officially reported to WHO increased from 29 000 to 53 000 between 2008 and 2010, still representing only 18% of the estimated 290 000 patients potentially identifiable if drug susceptibility testing was done in all notified cases of tuberculosis. A recent study done in Belarus showed a new global record for prevalence of MDR tuberculosis with 35·3% of new patients and 76·5% of previously treated patients diagnosed with the disease. This finding clearly shows how far case mismanagement can affect the chances to control (and eventually eliminate) the disease.
Unfortunately, since only a quarter of patients with tuberculosis are treated according to established standards and the proportion of treatment success does not exceed 50%, extensively drug-resistant (XDR) tuberculosis has already been reported in 77 countries and totally drug resistant cases (ie, Mycobacterium tuberculosis strains with resistance to all known drugs) have been recently described in Italy, Iran, and India.

Item Type:Article
ID Code:7983
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multidrug-resistant (MDR) tuberculosis, extensively drug-resistant (XDR) tuberculosis, Mycobacterium tuberculosis
Subjects:Area 06 - Scienze mediche > MED/01 Statistica medica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:Elsevier
eISSN:1474-547X
Deposited On:26 Sep 2012 13:45

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