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On linezolid efficacy and tolerability

De Lorenzo, Saverio and Centis, Rosella and D'Ambrosio, Lia and Sotgiu, Giovanni and Migliori, Giovanni Battista (2012) On linezolid efficacy and tolerability. European Respiratory Journal, Vol. 39 (3), p. 770-772. eISSN 1399-3003. Article.

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DOI: 10.1183/09031936.00116011

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Abstract

To further comment on the safety, tolerability and efficacy profile of linezolid in treating “difficult” tuberculosis (TB) cases, following the recent study by Villar et al., we here report on the experience of the E. Morelli Hospital in Sondalo, Italy, a reference centre for difficult-to-treat TB cases, e.g. those affected by multidrug-resistant (MDR)- and extensively drug-resistant (XDR)-TB, located in northern Italy.
As reported elsewhere, linezolid has been prescribed “off label” in Sondalo, Italy since 2005 to treat patients for whom at least four active drugs cannot be ensured, according to World Health Organization recommendations.
Administration of linezolid, within regimens designed to balance efficacy and tolerability, needs to be guided by clear scientific evidence focused on the ideal dosage (per kg body weight per day) and duration[...]

Item Type:Article
ID Code:7982
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multidrug-resistant (MDR)tuberculosis, extensively drug-resistant (XDR)-TB, northern Italy
Subjects:Area 06 - Scienze mediche > MED/01 Statistica medica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
Publisher:European Respiratory Society
eISSN:1399-3003
Deposited On:26 Sep 2012 10:33

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