Canu, Edoardo Domenico Giorgio and Magnano, Immacolata and Paulus, Kai Stephan and Piras, Maria Rita and Conti, Maurizio and Costantino, Salvatore and Nuvoli, Susanna Maria Francesca and Aiello, Isidoro Cesare Giuseppe (2005) Neuropsychophysiological findings in a case of long-standing overt ventriculomegaly (LOVA). Neuroscience Letters, Vol. 385 (1), p. 24-29. ISSN 0304-3940. eISSN 1872-7972. Article.
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Long-standing overt ventriculomegaly in adults (LOVA) is a clinical entity characterized by chronic hydrocephalus with infant onset, slow evolution and clinical disturbances during adulthood. Few cases are reported in literature describing the evident contrast between the severity of hydrocephalus and the relatively spared neurological functioning and cognitive aspects. The authors describe a 59-year-old man with congenital hydrocephalus complaining of persistent gait impairment. Neurological examination showed a mild paraparesis, severe higher cortical function impairment but relatively sparing of daily living activity. Computed tomography (CT) and magnetic resonance imaging (MRI) revealed a very remarkable ventriculomegaly compressing the brain cortex but sparing the cerebellum and the brainstem. Brain Single Photon Emission Computer Tomography (SPECT) showed a prevalent cerebellar perfusion as well. Neuropsychological testing was consistent with severe cognitive deterioration and attention disorders. Language and praxis functions seemed to be preserved. Auditory oddball ERPs (P300) showed morphological abnormalities especially of late components. This case report demonstrates in vivo the level of adaptation to which human brain can reach under chronic mechanic stress conditions. The striking poor cerebral parenchyma representation and the relatively spared language and praxic abilities account for a functional reorganization of residual structures due to the neural plasticity.
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