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Bronchoalveolar lavage immunodiagnosis for tuberculosis suspects in Europe and Africa

Lange, Christoph and Bossink, Aik and Eberhardt, Ralf and Goletti, Delia and Jafari, Claudia and Latorre, Irene and Kirsten, Detlef and Losi, Monica and Migliori, Giovanni Battista and Sotgiu, Giovanni (2010) Bronchoalveolar lavage immunodiagnosis for tuberculosis suspects in Europe and Africa. Thorax, Vol. 65 (9), p. 842. eISSN 1468-3296. Article.

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DOI: 10.1136/thx.2009.124958


We read with interest the article by Dheda et al1 who followed our approach for a rapid diagnosis of smear-negative tuberculosis by bronchoalveolar lavage (BAL) enzyme-linked immunospot (ELISpot)2 in a country of high tuberculosis incidence, including individuals with HIV-1 infection.
The authors report a sensitivity of 88.9% and specificity of 94.7% of the BAL ELISpot (T-SPOT.TB test) for the diagnosis of tuberculosis in suspects with scarce or negative acid-fast bacilli (AFB) sputum smears. This observation is important, as it confirms the findings of other [...]

Item Type:Article
ID Code:7959
Uncontrolled Keywords:Tuberculosis, bronchoalveolar lavage (BAL) enzyme-linked immunospot (ELISpot), Europe, Africa
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:BMJ Publishing Group
Deposited On:18 Sep 2012 09:18

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