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Availability of anti-tuberculosis drugs in Europe

Sotgiu, Giovanni and D'Ambrosio, Lia and Centis, Rosella and Bothamley, Graham Henry and Cirillo, Daniela M. and De Lorenzo, Saverio and Günther, Gunar and Kliiman, Kai and Muetterlein, Ralf and Spinu, Victor and Villar, Miguel and Zellweger, Jean-Pierre and Sandgren, Andreas and Huitric, Emma and Lange, Christoph and Manissero, Davide and Migliori, Giovanni Battista (2012) Availability of anti-tuberculosis drugs in Europe. European Respiratory Journal, Vol. 40 (2), p. 500-503. eISSN 1399-3003. Article.

Full text not available from this repository.

DOI: 10.1183/09031936.00009212

Abstract

The emergence of multidrug-resistant tuberculosis (MDR-TB) and extensively drug-resistant tuberculosis (XDR-TB) represents a major threat to TB control globally and, specifically, in Europe. MDR-/XDR-TB is at large due to clinical mismanagement of drug-susceptible and drug-resistant TB cases as well as to transmission of resistant strains [1–3]. Continuous availability of quality-controlled drugs is a prerequisite to ensure correct clinical management of TB patients.
Comprehensive and updated information on the availability and registration procedures of first-line (FLD) and second-line (SLD) anti-TB drugs is not available, neither in Europe nor elsewhere.
Anecdotal evidence suggested that in most European Union (EU) countries, where TB has a low incidence, procurement procedures are decentralised (not through Global Drug Facility, GDF), and with no specific responsibility for TB drug procurement available at the ministerial level. Despite high costs of SLD, registration procedures are strong enough to potentially prevent marketing and prescription of poor quality drugs. FLD and SLD are usually available (with mechanisms to prevent stock-outs), although the low number of drug doses sold can create challenges in assuring their continuous availability.

Item Type:Article
ID Code:7957
Status:Published
Refereed:Yes
Uncontrolled Keywords:Tuberculosis (TB), first-line (FLD) and second-line (SLD) anti-TB drugs availability, European Union countries
Subjects:Area 06 - Scienze mediche > MED/01 Statistica medica
Divisions:001 Università di Sassari > 01-a Nuovi Dipartimenti dal 2012 > Scienze Biomediche
001 Università di Sassari > 03 Istituti > Igiene e medicina preventiva
Publisher:European Respiratory Society
eISSN:1399-3003
Deposited On:17 Sep 2012 17:20

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