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MDR-TB and XDR-TB: drug resistance and treatment outcomes

Migliori, Giovanni Battista and Sotgiu, Giovanni and Richardson, Morgan D’Arcy and Centis, Rosella and Facchini, A. and Guenther, G. and Spanevello, Antonio and Lange, Christoph (2009) MDR-TB and XDR-TB: drug resistance and treatment outcomes. European Respiratory Journal, Vol. 34 (3), p. 778-779. eISSN 1399-3003. Article.

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DOI: 10.1183/09031936.00059409

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Abstract

We read with interest the study by HWANG et al., which continues the discussion on factors associated with poor outcomes in the treatment ofmultidrug-resistant tuberculosis (MDRTB) and extensively drug-resistant tuberculosis (XDR-TB).
The subject is quite topical, as TB programmes and clinicians are searching for solutions to treat MDR/XDR-TB most effectively. Recently published studies and a systematic review have shown that XDR-TB is associated with higher probability of failure and death, and lower probability of treatment success than MDR-TB. The XDR-TB-defining drugs have been studied to evaluate their role in determining successful outcomes in MDR/XDR-TB cases (XDR-TB is defined as resistance to at least isoniazid and rifampicin (MDR-TB) plus to any fluoroquinolone and at least one of three injectable anti-TB drugs (amikacin, capreomycin or kanamycin).

Item Type:Article
ID Code:7955
Status:Published
Refereed:Yes
Uncontrolled Keywords:Multidrug-resistant tuberculosis (MDR/XDR), extensively drug-resistant tuberculosis (XDR-TB), treatment
Subjects:Area 06 - Scienze mediche > MED/01 Statistica medica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
001 Università di Sassari > 03 Istituti > Igiene e medicina preventiva
Publisher:European Respiratory Society
eISSN:1399-3003
Deposited On:17 Sep 2012 13:57

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