Sotgiu, Giovanni and D'Ambrosio, Lia and Centis, Rosella and Bothamley, Graham Henry and Cirillo, Daniela M. and De Lorenzo, Saverio and Günther, Gunar and Kliiman, Kai and Muetterlein, Ralf and Spinu, Victor and Villar, Miguel and Zellweger, Jean-Pierre and Sandgren, Andreas and Huitric, Emma and Lange, Christoph and Manissero, Davide and Migliori, Giovanni Battista (2011) TB and M/XDR-TB infection control in European TB reference centres: the Achilles’ heel? European Respiratory Journal, Vol. 38 (5), p. 1221-1223. eISSN 1399-3003. Article.
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The emergence of multidrug-resistant (MDR) tuberculosis (TB), defined as in vitro resistance to isoniazid and rifampicin, and extensively drug-resistant (XDR)-TB, defined as in vitro drug resistance to isoniazid and rifampicin plus any fluoroquinolone and at least one of the injectable drugs (amikacin, capreomycin or kanamycin), represents a major threat to TB control at the global level. XDR-TB is a manmade product, resulting, in essence, from clinical mismanagement of newly diagnosed susceptible and resistant TB cases. Moreover, existing MDR/XDR-TB cases must be promptly detected and treated, and the transmission from infectious source cases has to be prevented, particularly in nosocomial settings.
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