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Trichomonas vaginalis haemolysis: evidence of functional pores formation on red cell membranes

Fiori, Pier Luigi and Rappelli, Paola and Rocchigiani, Angela Maria and Cappuccinelli, Pietro Antonio (1993) Trichomonas vaginalishaemolysis: evidence of functional pores formation on red cell membranes. FEMS Microbiology Letters, Vol. 109 (1), p. 13-18. eISSN 1574-6968. Article.

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Abstract

We have investigated the mechanisms used by Trichomonas vaginalis to damage cellular membranes, using human erythrocytes as target cells. Haemolysis is a contact- and temperature-dependent phenomenon, and is inhibited in 4 mM EGTA. Osmotic protection experiments using carbohydrates with different molecular diameters as protectants demonstrated that the cytolytic activity of T. vaginalis is inhibited in 75 mM stachyose. On the basis of our data, we hypothesize a cytopathic mechanism mediated by the formation of functional pores into the target membrane. Some of the Trichomonas protein involved in haemolysis have been immunologically characterized.

Item Type:Article
ID Code:7914
Status:Published
Refereed:Yes
Uncontrolled Keywords:Trichomonas vaginalis, haemolysis, cellular membranes
Subjects:Area 06 - Scienze mediche > MED/07 Microbiologia e microbiologia clinica
Divisions:001 Università di Sassari > 01 Dipartimenti > Scienze biomediche
Publisher:Blackwell / Wiley
eISSN:1574-6968
Deposited On:29 Aug 2012 17:35

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